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KMID : 0373919770170000023
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1977 Volume.17 No. 0 p.23 ~ p.32
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The Influence of Glucocorticoid on Insulin and Glucose Concentration in Blood
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Abstract
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It has been reported that glucocorticoid causes the increase of blood sugar.
In this study, it was studied on the influence of glucocorticoid on insulin and glucose in blood according as blood sugar value changes.
Cortisone succinate and prednisolone acetate-these are synthetic glucocorticoid-were injected to the rabbits and their blood sugar and blood insulin values were observed. Bloc) 1 sugar was measured by Somogyi-Nelson method and the isolated rat diaphragms
were used in the biological assay of insulin. Glucose tolerance tests were applied to the #-abbits.
The results of this study followed
1) Il1ood sugar was increased by glucocorticoid and blood sugar value was twice than normal in the 7th day of the treatment of glucocorticoid.
2) Insulin value decreased than normal. So increased blood sugar value did not control by insulin.
3) glucose tolerance test was not normal in the last day of the treatment of glucocorticoid. But it was normal in the 30th day when glucocorticoid had stopped to inject.
It Was certain that the action controlling blood sugar value was inhibited byglucocorticoid from these results.
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KEYWORD
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